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Modeling the molecular response of single cells to drug perturbations

Artur Szalata (Ph.D. Student)

Biological single-cell sequencing data can be used to learn about cellular phenotypes, developmental trajectories, and disease. It is increasingly utilized to measure a cell's molecular state across perturbations. To better understand a cellular system, we develop a machine learning model that can accurately predict drug-induced perturbations in multiomic single-cell readouts. We focus on an interpretable deep-learning approach applicable to a wide range of cell-types and perturbations. Such a generic model facilitates the design of optimal treatments, and can be used to generate and validate hypotheses about underlying biological processes.

Primary Host: Fabian Theis (Helmholtz Center Munich)
Exchange Host: Christoph Bock (CeMM Research Center for Molecular Medicine)
PhD Duration: 01 November 2022 - 01 November 2025
Exchange Duration: 01 November 2023 - 01 May 2024 - Ongoing