ELLIS against Covid-19

Leveraging single-cell transcriptomics to understand the molecular basis for SARS-CoV-2 distribution in the population

ellis 15 April 2020 - 15 April 2020
15 April 2020 • 13:40 - 13:55

(Helmholtz Zentrum München)

Single-cell technologies nowadays give us easy and large-scale access to cell-state observations on the transcriptomic and epigenomic level. Within the Human Cell Atlas Lung Biological Network, we aim to identify the distribution of SARS-CoV-2 cell entry genes across more than 1.1M transcriptomes from 164 individuals. In particular we can link variation in age, gender and smoking status to cell-type specific expression. The underlying transcriptome networks provide hypotheses on how infection rates differ across the population and motivate targeted studies and perturbation experiments.



Thumb ticker fabian theis
(Helmholtz Center Munich)